It’s a UNESCO. For example, we say a UNESCO World Heritage Site, a UNESCO project, a UNESCO study, etc. Since the word UNESCO begins with a consonant sound ("you"), we use the article a.
The reef has been listed a UNESCO World Heritage Site.
The reef has
It’s an SEO. The abbreviation SEO is usually pronounced as individual letters. Since the consonant "S" begins with a vowel sound ("ess"), we use the article "an".