When expressing your opinion, attitude, or judgement, use commas to set off the words "frankly", "honestly", "truthfully", or "admittedly".

At the beginning of a sentence, follow the sentence adverbs "sadly", "unfortunately", "regrettably", and "unhappily" with a comma.

In front position, the sentence adverbs "fortunately", "happily", and "luckily" should be followed by a comma. Commas are generally unnecessary when these adverbs modify a single word (verb, adverb, or adjective).

When acting like an introduction at the beginning of a sentence, add a comma after the expressions "generally", "generally speaking", or "in general".

At the beginning of a sentence, add a comma after the words "technically", "scientifically", "psychologically", "medically", "economically", "financially", etc. to place your statement in a particular context.

We do not typically use a comma before or after an adverb of degree in a sentence. But there are particular situations where you may need to use commas.

When starting a sentence with an adverb, an introductory phrase, or an adverb clause of manner, we often add a comma after it.

We do not generally use a comma to separate an adverb of place from the rest of the sentence. There are situations, however, where the particular sentence structure requires a comma before or after an adverb of place or an adverb clause.

We do not generally use a comma to separate a regular adverb of time from the rest of the sentence. But you can use commas to set off nonessential information, add long introductory phrases, avoid confusion, or stress a pause.