Is It an HPV or a HPV?

It’s an HPV. Because the letter H starts with a vowel sound (similar to "eich"), we use "an" before the abbreviation HPV (Human Papilloma Virus).
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Is It a HDD or an HDD?

Both are correct. When pronouncing HDD as individual letters, we say "an HDD". By contrast, when pronouncing the acronym as words (Hard Disk Drive), we put the article "a".
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Is It an HIV Test or a HIV Test?

It’s an HIV test. Since we commonly pronounce HIV as individual letters, and the "H" sounds like "eich", we use the indefinite article "an".
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Is It an HDMI Cable or a HDMI Cable?

It’s an HDMI cable. Since the initial letter of the abbreviation HDMI (High-Definition Multimedia Interface) sounds like "eich", we use "an".
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Is It an HDL or a HDL?

It’s an HDL. The abbreviation HDL is typically pronounced as individual letters. Since the first letter, the h, starts with a vowel sound (aich), it takes the article "an".
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Is It an H or a H?

It’s an H. Because the character H starts with a vowel sound (aitch), we use the indefinite article "an".
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